Downregulation of major histocompatibility complex class I in bovine papillomas
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چکیده
منابع مشابه
Frequency of Major Histocompatibility Antigens Class I in Mazandaran Province
Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran. Materials and methods: In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center af...
متن کاملMajor Histocompatibility Complex, Class I, B
Description The genes of the Human Leukocyte Antigen (HLA) system reside on chromosome 6, and code for cellsurface proteins that play a crucial role in the presentation of endogenic peptides to effector cells of the immune system. The HLA Class I protein molecule is a heterodimer, made up of two chains; a heavy one and a light one (beta 2 microglobulin). The HLA-B gene is one of the three HLA C...
متن کاملEfficient downregulation of major histocompatibility complex class I molecules in human epithelial cells infected with cytomegalovirus.
Liver and intestinal epithelial cells are a major target of infection by cytomegaloviruses (CMV), causing severe disease in affected organs of immunocompromised patients. CMV downregulates major histocompatibility complex class I (MHC-I) molecule expression in fibroblasts in order to avoid lysis by CD8(+) cytotoxic T lymphocytes. However, MHC-I expression in human cytomegalovirus (HCMV)-infecte...
متن کاملGenetic and epigenetic regulation of major histocompatibility complex class I gene expression in bovine trophoblast cells
PROBLEM The regulatory mechanisms governing differential expression of classical major histocompatibility complex (MHC) class I (MHC-Ia) and non-classical MHC class I (MHC-Ib) genes are poorly understood. METHOD OF STUDY Quantitative reverse transcription- polymerase chain reaction (PCR) was used to compare the abundance of MHC-I transcripts and related transcription factors in peripheral blo...
متن کاملDetermination of the Expression Patterns of Bovine Non-Classical Major Histocompatibility Complex (MHC) Class I Proteins
Determination of the Expression Patterns of Bovine Non-Classical Major Histocompatibility Complex (MHC) Class I Proteins
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2004
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.80128-0